Taken the facility layout in typical final assembly workshop of offshore wind turbine generator as the research object, the workshop facility layout theory is introduced, and the mathematical model of facility layout in final assembly workshop of offshore wind turbine generator is established based on Systematic Layout Planning (SLP) and genetic algorithm. The logistics relationship of workshop routing is analyzed, and the facility layout design of typical final assembly workshop of offshore wind turbine generator is optimized with the optimization goal of minimum logistics intensity. The research results are of certain reference significance for the discrete manufacturing industry to optimize the workshop facility layout and reduce the production cost.