The pressure-stable and clean supply of ship fuel is studied, and a pressure regulation and filtration supply system for ship fuel is designed. The fuel filtration supply system can effectively filter the impurities and improve the fuel quality. The fuel pressure regulation supply tank can realize the pressure regulation inside the tank body and ensure the stability of fuel supply pressure. The pressure regulation and filtration supply system for ship fuel combined the advantages of fuel filtration supply system and fuel pressure regulation supply tank can ensure the good operation of ship engine and be of the higher practical application value.