With the wide application of large robot welding workstations with multi-robot cooperative operation, higher requirements are proposed for the robot safety protection strategy to meet the safety production needs of enterprises. On the basis of the analysis of risk factors of large robot welding workstation, focused on the equipment collision and personnel safety, a clear configuration scheme is proposed for the safety protection of robot body, upper computer control system, visual safety system, and physical limit, which is verified and applied in the actual welding workstation.