In view of the large size, heavy mass, great installation difficulty, etc. of main thruster equipment of Cargo Transfer Vessel (CTV), the main thruster foundation is set for the connection and installation of stern structure and main thruster. The design, manufacturing, and installation technology of main thruster foundation is studied in detail. The reasonable structural design of main thruster foundation is made, and the effective welding procedure and installation flow are determined, which can ensure the structural stability and the manufacturing and installation accuracy of the foundation.