Based on the whole ship structural strength analysis results of large luxury cruise ship, the typical types of superstructure side doors and windows are selected for the detailed model strength analysis. Based on the coarse mesh results, the detailed model calculation is made for the side door and window structure, the detailed stress distribution law of opening structure is obtained, and the position where the stress value exceeds the specification is strengthened by adding the insert plate. After the structural optimization, the corresponding areas meet the strength requirements. The research results can provide reference for the design of superstructure side doors and windows of large luxury cruise ship.