Taken the high-end ro-ro passenger ship W0267 as the research object, combined with the relevant constraints of specifications and the relevant requirements of home port, the ro-ro passenger ship Braille signage system is designed. According to the design flow of Braille layout plan, the design considerations of Braille signs are determined, the effective life routes and escape routes are established, and the Braille layout plan is firmed finally. The research can provide technological support for improving the phenomena of function lack and sign confusion in ship signage system and building a humanized and standardized ship signage space.