Taken a Very Large Ore Carrier (VLOC) for example, based on Guidelines for Direct Strength Analysis of Hull Structure of Ore Carriers and Guidelines for Advanced Buckling Assessment of Hull Structure of Ore Carriers of CCS, the calculation and analysis of column buckling, torsional buckling, and combined torsional/column buckling strength of typical crosstie structure on the transverse frame in the VLOC wing tank are made. In terms of the stress characteristics of VLOC crosstie structure, through the comparison of several cross section shapes and influence analysis of horizontal girder breadth, panel eccentricity, and other related design parameters, some guiding suggestions are given for improving the cross section shape design and material selection of VLOC crosstie.