In order to improve the accuracy of hull precision compensation design and improve the original groove retention rate of ship general assembly procedure, the construction data of a certain type of offshore engineering product under construction are taken for example. Through the multiple linear regression theory, a optimization calculation method of compensation quantity is given, the prediction calculation formula of precision compensation is obtained, and the corresponding calculation program is written. The method is of strong applicability, which can calculate the compensation values of each type of section in different procedure and optimize the ship construction compensation system.