In order to study the damage effect of typical cabin structure under the implosion load, in terms of the typical cabin structure of large ships, combined with the empirical calculation formula of shock wave load, a simplified algorithm is adopted to calculate the overall plate frame damage of explosion cabin, and the numerical simulation method is used to verify. The damage mode of typical cabin structure under the action of conventional anti-ship missile is analyzed. According to the implosion test results of related large-scale model, the plate frame failure mode of explosion cabin is studied, and the simplified algorithm is verified again by the test results. The results show that the simplified algorithm is of certain reliability and accuracy.