A type of high-speed passenger ship is taken as the research object. The CAESES FRIENDSHIP-Framework software is used to make the full parameterization modeling, the SHIPFLOW software is used to calculate the wave-making resistance of original model, and the calculated results are compared with the ship model test results to verify the calculation reliability. The Sobol algorithm is used to calculate the sensitivity of characteristic parameters to effectively reduce the design space dimensions and improve the calculation efficiency. A multiple speed optimization model is established to complete the wave-making resistance optimization of hull bow. The results show that the wave-making resistance of optimization model is significantly lower than that of original model at multiple speeds, and the research results are of certain practical value in the engineering.