By taking the liquid tank hoisting of cargo area of 37 500 m3 Liquefied Ethylene Gas (LEG）ship as the research object, the interference check and data matching before the liquid tank hoisting are sorted out to establish a complete set of liquid tank hoisting simulation matching flow, and the solutions to the problems during the actual hoisting are proposed, which aims to provide reference and accumulate experience for the subsequent similar large liquid tank hoisting.