With the urgent global demand for clean energy, offshore wind power has attracted attention as an important source of renewable energy. In the process of offshore wind turbine hoisting operation, the load factors of waves, wind and current have a great influence on the dynamics of the offshore wind turbine hoisting system. In order to better explore the dynamic response of environmental load to the whole hoisting system during the hoisting process, this paper uses the marine engineering software AQWA based on the three-dimensional potential flow theory to establish a coupling model between the 3600-ton full-swing crane ship and the hoisting equipment, and sets up a two-end catenary mooring system to study the dynamic response of the environmental load to the hoisting system of the wind turbine. The results show that the crane vessel should operate in the same wave or against the wave, and avoid operating in the wave frequency range corresponding to the maximum motion response, so as to ensure the safety and stability of the operation. The research results of this paper play a certain reference and guiding significance for the hoisting operation of crane ships at sea.