Abstract Aiming at the problems of long moving routes, chaotic routes, and easy collision of cabin modules with obstacles during the transportation of large cruise cabin modules, an ant colony algorithm with dynamic search model is proposed to plan the route of cruise cabins. Provide a clear and convenient transfer route for workers to transport cabin modules. Analyze the obstacles in the main vertical zone, establish a grid map that simulates the actual working conditions, and use the improved ant colony algorithm to find the migration path; Dynamically adjust the grid map and the number of ant colonies passing through different positions; Through simulated annealing the algorithm seeks the parameters of the ant colony algorithm; The main and branch channels of the migration path are determined by discrete point analysis. The simulation results has showed that the proposed algorithm can effectively improve the transportation efficiency of cabin.