In order to exploit deep-sea oil and gas resources, FPSO pipeline systems often face extremely harsh deep-sea operating environments. Therefore, it is extremely necessary to carry out detailed stress analysis and verification of FPSO pipeline systems. Waves act on the hull and pipeline supports to generate acceleration loads, and different accelerations are generated at different positions of the pipeline. In the traditional method, the acceleration at the center of gravity of the ship is often used to replace the acceleration at each position, and the acceleration load analysis is performed on the FPSO pipeline. This method is difficult to FPSO Piping system for accurate load analysis. With the help of classification society rules and MATLAB software, a program that can extract the acceleration at any position of the FPSO pipeline is developed to facilitate better stress analysis of the FPSO pipeline system. Taking the FPSO main deck cooling water system as an example, the actual acceleration value at any position of the system and the acceleration value at the center of gravity of the FPSO ship are respectively applied to the pipeline in the form of uniform load, and the CAESAR II software is used to analyze the stress of the pipeline system under full load conditions. Variety. The results show that under the full load condition of FPSO, the results obtained by using the acceleration value at the center of gravity will have stress redundancy and insufficient stress compared with the actual acceleration value. For example, the stress of node 50 increases by 1.01%, while the 2570 stress is reduced by 0.19%.